| 1 | Madrigal Pharmaceuticals Inc | 1,993,687 | 1B $ | |
| 2 | Insmed Inc | 4,842,880 | 791.9M $ | |
| 3 | Protagonist Therapeutics Inc | 5,059,053 | 533.2M $ | |
| 4 | PTC Therapeutics Inc | 7,746,415 | 527.8M $ | |
| 5 | Argenx SE | 709,446 | 518.1M $ | |
| 6 | CG oncology Inc | 6,984,808 | 472.7M $ | |
| 7 | Celcuity Inc | 3,039,621 | 346.9M $ | |
| 8 | Tango Therapeutics Inc | 13,300,620 | 278.2M $ | |
| 9 | Erasca Inc | 16,157,175 | 261.4M $ | |
| 10 | Natera Inc | 1,250,000 | 250M $ | |
| 11 | RadNet Inc | 4,285,000 | 239.5M $ | |
| 12 | Tarsus Pharmaceuticals Inc | 3,346,025 | 234.7M $ | |
| 13 | Apogee Therapeutics Inc | 2,782,097 | 234.2M $ | |
| 14 | Spyre Therapeutics Inc | 4,171,996 | 210.4M $ | |
| 15 | Cogent Biosciences Inc | 5,458,675 | 210.1M $ | |
| 16 | IRhythm Holdings Inc | 1,668,500 | 196.9M $ | |
| 17 | Stoke Therapeutics Inc | 5,623,525 | 183.1M $ | |
| 18 | Cytokinetics Inc | 2,721,158 | 179.4M $ | |
| 19 | ACADIA Pharmaceuticals Inc | 7,144,524 | 159M $ | |
| 20 | Apellis Pharmaceuticals Inc | 3,685,045 | 148.2M $ | |
| 21 | Immunocore Holdings PLC | 4,869,798 | 146.8M $ | |
| 22 | Repligen Corp | 1,206,000 | 142.1M $ | |
| 23 | Neurocrine Biosciences Inc | 1,062,072 | 139.9M $ | |
| 24 | Guardant Health Inc | 1,481,033 | 136.8M $ | |
| 25 | ZAI LAB LTD | 6,574,032 | 123.7M $ | |
| 26 | Belite Bio Inc | 715,332 | 114.1M $ | |
| 27 | Intuitive Surgical Inc | 220,000 | 101.4M $ | |
| 28 | Oruka Therapeutics Inc | 2,058,148 | 101M $ | |
| 29 | Xencor Inc | 6,777,461 | 81.7M $ | |
| 30 | CENTESSA PHARMACEUTICALS PLC | 2,054,175 | 81.6M $ | |
| 31 | Immunovant Inc | 3,177,849 | 78.9M $ | |
| 32 | Ultragenyx Pharmaceutical Inc | 3,648,795 | 76.4M $ | |
| 33 | Hinge Health Inc | 1,930,000 | 74.4M $ | |
| 34 | Castle Biosciences Inc | 2,758,335 | 67.7M $ | |
| 35 | Rocket Pharmaceuticals Inc | 17,687,772 | 63.3M $ | |
| 36 | Taysha Gene Therapies Inc | 13,680,248 | 61.2M $ | |
| 37 | Compass Pathways plc | 10,632,390 | 58.8M $ | |
| 38 | Kodiak Sciences Inc | 1,487,934 | 56.7M $ | |
| 39 | Replimune Group Inc | 7,356,916 | 56.3M $ | |
| 40 | Crinetics Pharmaceuticals Inc | 1,451,326 | 52.7M $ | |
| 41 | Waystar Holding Corp | 1,630,000 | 39.3M $ | |
| 42 | Arrowhead Pharmaceuticals Inc | 585,682 | 36.7M $ | |
| 43 | Orchestra BioMed Holdings Inc | 8,306,063 | 35.3M $ | |
| 44 | Verastem Inc | 6,576,306 | 34.9M $ | |
| 45 | Evommune Inc | 1,502,235 | 34.5M $ | |
| 46 | Stryker Corp | 100,000 | 32.9M $ | |
| 47 | Savara Inc | 5,952,380 | 32.5M $ | |
| 48 | Candel Therapeutics Inc | 6,422,018 | 31.5M $ | |
| 49 | Aquestive Therapeutics Inc | 7,426,471 | 30.8M $ | |
| 50 | Aktis Oncology Inc | 1,592,043 | 28.5M $ | |
| 51 | Neurogene Inc | 1,362,456 | 27.5M $ | |
| 52 | Cullinan Therapeutics Inc | 1,705,960 | 24.2M $ | |
| 53 | Compass Therapeutics Inc | 4,186,599 | 22.1M $ | |
| 54 | Dianthus Therapeutics Inc | 248,063 | 20.8M $ | |
| 55 | Fulgent Genetics Inc | 1,289,000 | 20.5M $ | |
| 56 | Beta Bionics Inc | 2,000,000 | 20M $ | |
| 57 | Kymera Therapeutics Inc | 240,000 | 20M $ | |
| 58 | Century Therapeutics Inc | 8,695,652 | 19.7M $ | |
| 59 | Beam Therapeutics Inc | 570,394 | 13.6M $ | |
| 60 | AVALO THERAPEUTICS INC | 856,962 | 12.8M $ | |
| 61 | Ocugen Inc | 6,666,666 | 12.1M $ | |
| 62 | HeartFlow Inc | 495,000 | 12M $ | |
| 63 | JADE BIOSCIENCES INC | 573,205 | 8.1M $ | |
| 64 | Capricor Therapeutics Inc | 250,000 | 7.6M $ | |
| 65 | KALARIS THERAPEUTICS INC | 1,300,000 | 7.5M $ | |
| 66 | Inventiva SACA | 1,298,702 | 7.2M $ | |
| 67 | AtaiBeckley Inc | 2,000,000 | 7.1M $ | |
| 68 | Larimar Therapeutics Inc | 1,500,000 | 6.8M $ | |
| 69 | Tenax Therapeutics Inc | 370,246 | 5.9M $ | |
| 70 | Lumexa Imaging Holdings Inc | 650,000 | 5.6M $ | |
| 71 | 4D Molecular Therapeutics Inc | 475,737 | 4.4M $ | |
| 72 | Medline Inc | 70,000 | 3.1M $ | |
| 73 | Omada Health Inc | 200,000 | 2.5M $ | |
| 74 | Disc Medicine Inc | 30,000 | 1.9M $ | |
| 75 | IMAGENEBIO INC | 334,445 | 1.7M $ | |
| 76 | Exagen Inc | 395,231 | 1.2M $ | |