| 1 | Ascendis Pharma A/S | 10 281 496 | 2,4 Md $ | |
| 2 | Vaxcyte Inc | 11 474 599 | 666,8 M $ | |
| 3 | Rhythm Pharmaceuticals Inc | 6 666 837 | 579,8 M $ | |
| 4 | Tyra Biosciences Inc | 12 198 625 | 467,2 M $ | |
| 5 | Sionna Therapeutics Inc | 9 905 045 | 397,1 M $ | |
| 6 | Edgewise Therapeutics Inc | 10 428 437 | 328,5 M $ | |
| 7 | Nuvalent Inc | 2 534 145 | 259,6 M $ | |
| 8 | Dianthus Therapeutics Inc | 2 611 733 | 219,2 M $ | |
| 9 | Mineralys Therapeutics Inc | 7 692 750 | 208,4 M $ | |
| 10 | SpyGlass Pharma Inc | 8 021 117 | 207,8 M $ | |
| 11 | Septerna Inc | 6 995 858 | 168,1 M $ | |
| 12 | Disc Medicine Inc | 2 450 221 | 156,7 M $ | |
| 13 | Janux Therapeutics Inc | 11 189 693 | 155,5 M $ | |
| 14 | BioCryst Pharmaceuticals Inc | 15 827 186 | 150,7 M $ | |
| 15 | Bicara Therapeutics Inc | 7 255 993 | 144,3 M $ | |
| 16 | Praxis Precision Medicines Inc | 373 787 | 120,4 M $ | |
| 17 | ZAI LAB LTD | 5 707 262 | 107,4 M $ | |
| 18 | Taysha Gene Therapies Inc | 23 555 648 | 105,3 M $ | |
| 19 | Vor BioPharma Inc | 5 404 998 | 96,4 M $ | |
| 20 | Geron Corp | 63 771 366 | 95 M $ | |
| 21 | ARS Pharmaceuticals Inc | 10 860 977 | 87,2 M $ | |
| 22 | Sarepta Therapeutics Inc | 3 902 596 | 84,9 M $ | |
| 23 | Spyre Therapeutics Inc | 1 621 620 | 81,8 M $ | |
| 24 | Evommune Inc | 3 494 638 | 80,3 M $ | |
| 25 | Climb Bio Inc | 11 300 939 | 77,4 M $ | |
| 26 | Solid Biosciences Inc | 9 339 978 | 67,2 M $ | |
| 27 | Artiva Biotherapeutics Inc | 9 853 302 | 63,5 M $ | |
| 28 | DAMORA THERAPEUTICS INC | 2 399 310 | 62,1 M $ | |
| 29 | Xencor Inc | 4 897 237 | 59,1 M $ | |
| 30 | LB Pharmaceuticals Inc | 2 208 604 | 54,5 M $ | |
| 31 | JADE BIOSCIENCES INC | 3 671 083 | 51,6 M $ | |
| 32 | Acumen Pharmaceuticals Inc | 20 992 669 | 49,5 M $ | |
| 33 | 4D Molecular Therapeutics Inc | 5 049 779 | 47 M $ | |
| 34 | Fulcrum Therapeutics Inc | 6 053 960 | 46,4 M $ | |
| 35 | Capricor Therapeutics Inc | 1 507 844 | 45,8 M $ | |
| 36 | Century Therapeutics Inc | 17 754 430 | 40,1 M $ | |
| 37 | Olema Pharmaceuticals Inc | 2 600 000 | 38,8 M $ | |
| 38 | LENZ Therapeutics Inc | 4 178 823 | 38,2 M $ | |
| 39 | Monopar Therapeutics Inc | 667 207 | 36,6 M $ | |
| 40 | PepGen Inc | 20 064 545 | 35,5 M $ | |
| 41 | Design Therapeutics Inc | 2 972 973 | 31,6 M $ | |
| 42 | Mirum Pharmaceuticals Inc | 318 554 | 29,4 M $ | |
| 43 | BioAge Labs Inc | 1 650 648 | 28,9 M $ | |
| 44 | Lexeo Therapeutics Inc | 5 000 000 | 28,7 M $ | |
| 45 | Assembly Biosciences Inc | 1 020 410 | 28,3 M $ | |
| 46 | Rezolute Inc | 9 180 000 | 28 M $ | |
| 47 | Aktis Oncology Inc | 1 503 084 | 26,9 M $ | |
| 48 | ALX Oncology Holdings Inc | 13 011 849 | 26,1 M $ | |
| 49 | Aclaris Therapeutics Inc | 6 804 072 | 25,5 M $ | |
| 50 | Ovid therapeutics Inc | 10 714 000 | 23,8 M $ | |
| 51 | Nkarta Inc | 10 805 129 | 22,8 M $ | |
| 52 | Travere Therapeutics Inc | 746 841 | 22,2 M $ | |
| 53 | GRAIL Inc | 428 266 | 22,1 M $ | |
| 54 | C4 Therapeutics Inc | 8 000 000 | 21 M $ | |
| 55 | Relmada Therapeutics Inc | 2 947 369 | 20,5 M $ | |
| 56 | Benitec Biopharma Inc | 1 850 000 | 19,7 M $ | |
| 57 | Sutro Biopharma Inc | 715 307 | 17,8 M $ | |
| 58 | Contineum Therapeutics Inc | 1 296 012 | 16,9 M $ | |
| 59 | SAB Biotherapeutics Inc | 4 401 500 | 16,9 M $ | |
| 60 | Inspire Medical Systems Inc | 325 663 | 16,8 M $ | |
| 61 | Anteris Technologies Global Corp | 3 000 000 | 16,7 M $ | |
| 62 | OnKure Therapeutics Inc | 3 998 333 | 16,6 M $ | |
| 63 | Hinge Health Inc | 364 613 | 14,1 M $ | |
| 64 | GeneDx Holdings Corp | 209 887 | 13,5 M $ | |
| 65 | Waystar Holding Corp | 529 400 | 12,8 M $ | |
| 66 | Palisade Bio Inc | 7 124 116 | 12,5 M $ | |
| 67 | Acrivon Therapeutics Inc | 8 340 508 | 11,6 M $ | |
| 68 | Atrium Therapeutics Inc | 864 102 | 11,6 M $ | |
| 69 | Karyopharm Therapeutics Inc | 1 917 354 | 10,7 M $ | |
| 70 | AVALO THERAPEUTICS INC | 662 968 | 9,9 M $ | |
| 71 | Adicet Bio Inc | 1 182 624 | 8,1 M $ | |
| 72 | Corvus Pharmaceuticals Inc | 450 000 | 6,6 M $ | |
| 73 | Rani Therapeutics Holdings Inc | 8 500 000 | 6,2 M $ | |
| 74 | Equillium Inc | 3 096 336 | 6,2 M $ | |
| 75 | WEREWOLF THERAPEUTICS INC | 6 681 307 | 5,6 M $ | |
| 76 | MacroGenics Inc | 1 864 176 | 5,4 M $ | |
| 77 | MapLight Therapeutics Inc | 248 294 | 5 M $ | |
| 78 | PALATIN TECHNOLOGIES INC | 70 000 | 1,2 M $ | |