| 1 | Praxis Precision Medicines Inc | 2,035,986 | 656M $ | |
| 2 | Celcuity Inc | 3,127,200 | 356.9M $ | |
| 3 | Ascendis Pharma A/S | 1,531,421 | 350.3M $ | |
| 4 | CENTESSA PHARMACEUTICALS PLC | 5,258,903 | 208.9M $ | |
| 5 | Rhythm Pharmaceuticals Inc | 2,373,795 | 206.4M $ | |
| 6 | Spyre Therapeutics Inc | 3,783,225 | 190.8M $ | |
| 7 | Nuvalent Inc | 1,580,505 | 161.9M $ | |
| 8 | Edgewise Therapeutics Inc | 4,423,974 | 139.4M $ | |
| 9 | Protagonist Therapeutics Inc | 1,230,879 | 129.7M $ | |
| 10 | Apogee Therapeutics Inc | 1,540,384 | 129.7M $ | |
| 11 | Travere Therapeutics Inc | 4,142,551 | 123.1M $ | |
| 12 | Amylyx Pharmaceuticals Inc | 8,284,882 | 115.2M $ | |
| 13 | Relay Therapeutics Inc | 9,751,141 | 97M $ | |
| 14 | Inhibrx Biosciences Inc | 1,442,707 | 97M $ | |
| 15 | Zymeworks Inc | 3,510,078 | 87.9M $ | |
| 16 | Solid Biosciences Inc | 11,906,646 | 85.7M $ | |
| 17 | Dyne Therapeutics Inc | 4,668,839 | 84.6M $ | |
| 18 | BioCryst Pharmaceuticals Inc | 7,434,033 | 70.8M $ | |
| 19 | Oruka Therapeutics Inc | 1,395,501 | 68.4M $ | |
| 20 | Artivion Inc | 1,637,290 | 60M $ | |
| 21 | Nurix Therapeutics Inc | 3,710,877 | 57.5M $ | |
| 22 | Nautilus Biotechnology Inc | 12,594,211 | 48.9M $ | |
| 23 | CytomX Therapeutics Inc | 10,098,824 | 47.5M $ | |
| 24 | Alto Neuroscience Inc | 2,009,893 | 45.2M $ | |
| 25 | Immunovant Inc | 1,597,383 | 39.7M $ | |
| 26 | Intuitive Surgical Inc | 85,419 | 39.4M $ | |
| 27 | Ionis Pharmaceuticals Inc | 504,000 | 37.8M $ | |
| 28 | Day One Biopharmaceuticals Inc | 1,755,799 | 37.6M $ | |
| 29 | Abivax SA | 328,884 | 36.6M $ | |
| 30 | Corvus Pharmaceuticals Inc | 2,292,441 | 33.5M $ | |
| 31 | Repligen Corp | 280,541 | 33.1M $ | |
| 32 | DAMORA THERAPEUTICS INC | 1,223,000 | 31.7M $ | |
| 33 | X4 PHARMACEUTICALS INC | 6,737,648 | 27.8M $ | |
| 34 | Guardant Health Inc | 300,000 | 27.7M $ | |
| 35 | Invivyd Inc | 20,859,303 | 27.1M $ | |
| 36 | Sionna Therapeutics Inc | 658,439 | 26.4M $ | |
| 37 | Axsome Therapeutics Inc | 149,950 | 25.3M $ | |
| 38 | Revolution Medicines Inc | 258,600 | 25.1M $ | |
| 39 | SAB Biotherapeutics Inc | 6,431,743 | 24.6M $ | |
| 40 | Belite Bio Inc | 151,979 | 24.2M $ | |
| 41 | Tenax Therapeutics Inc | 1,447,782 | 23.2M $ | |
| 42 | Axogen Inc | 697,312 | 23.1M $ | |
| 43 | Viridian Therapeutics Inc | 1,170,829 | 22.9M $ | |
| 44 | Orchestra BioMed Holdings Inc | 5,037,906 | 21.4M $ | |
| 45 | Rapport Therapeutics Inc | 673,923 | 21.1M $ | |
| 46 | DBV Technologies SA | 964,391 | 20.1M $ | |
| 47 | LeonaBio Inc | 1,859,322 | 19.1M $ | |
| 48 | Anteris Technologies Global Corp | 3,425,476 | 19M $ | |
| 49 | Sutro Biopharma Inc | 715,307 | 17.8M $ | |
| 50 | Tango Therapeutics Inc | 808,153 | 16.9M $ | |
| 51 | Contineum Therapeutics Inc | 1,255,592 | 16.4M $ | |
| 52 | Palisade Bio Inc | 8,928,149 | 15.6M $ | |
| 53 | IRhythm Holdings Inc | 105,026 | 12.4M $ | |
| 54 | ADAGIO MEDICAL HOLDINGS INC | 9,876,576 | 11M $ | |
| 55 | Evommune Inc | 448,350 | 10.3M $ | |
| 56 | Phathom Pharmaceuticals Inc | 925,000 | 10.3M $ | |
| 57 | Neumora Therapeutics Inc | 5,104,097 | 10M $ | |
| 58 | Omada Health Inc | 786,330 | 9.9M $ | |
| 59 | Neurocrine Biosciences Inc | 65,050 | 8.6M $ | |
| 60 | Beta Bionics Inc | 842,944 | 8.4M $ | |
| 61 | Opus Genetics Inc | 1,835,842 | 8.4M $ | |
| 62 | Billiontoone Inc | 91,812 | 7.2M $ | |
| 63 | Twist Bioscience Corp | 150,000 | 7.1M $ | |
| 64 | Surrozen Inc | 229,393 | 6.7M $ | |
| 65 | AGOMAB THERAPEUTICS SA | 600,000 | 6.3M $ | |
| 66 | Evolus Inc | 1,286,862 | 5.3M $ | |
| 67 | Cogent Biosciences Inc | 121,082 | 4.7M $ | |
| 68 | ADMA Biologics Inc | 467,233 | 4.2M $ | |
| 69 | Inhibikase Therapeutics Inc | 2,315,000 | 3.9M $ | |
| 70 | Apellis Pharmaceuticals Inc | 80,956 | 3.3M $ | |
| 71 | Outset Medical Inc | 833,333 | 3.2M $ | |
| 72 | Adaptive Biotechnologies Corp | 152,500 | 2.1M $ | |
| 73 | AVALO THERAPEUTICS INC | 139,667 | 2.1M $ | |
| 74 | Corcept Therapeutics Inc | 50,000 | 2M $ | |
| 75 | Medline Inc | 28,000 | 1.2M $ | |
| 76 | PALATIN TECHNOLOGIES INC | 61,945 | 1.1M $ | |
| 77 | Cumberland Pharmaceuticals Inc | 196,978 | 640.2K $ | |
| 78 | REVOLUTION MEDICINES INC WTS 12/26 | 250,000 | 447.5K $ | |
| 79 | Exagen Inc | 114,893 | 344.7K $ | |
| 80 | ENSYSCE BIOSCIENCES INC | 86,666 | 46.7K $ | |