Funds holding Ionis Pharmaceuticals Inc
431 funds declare a position · 100 ETFs and 331 other funds · 6.6B $· 346.9M SEK· 4M € · US4622221004
Each line carries its report date.
| Rank | Fund | Shares | Value | Weight | |
|---|---|---|---|---|---|
| 1 | Fidelity Growth Company Fund Fidelity Mt. Vernon Street Trust | 8,111,335 | 658.2M $ | 0.80 % | as of Feb 28, 2026 · Original filing |
| 2 | Growth Fund of America Growth Fund of America | 7,668,655 | 622.3M $ | 0.19 % | as of Feb 28, 2026 · Original filing |
| 3 | VANGUARD TOTAL STOCK MARKET INDEX FUND VANGUARD INDEX FUNDS | 4,995,141 | 375.1M $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 4 | New Economy Fund New Economy Fund | 4,723,802 | 383.3M $ | 0.85 % | as of Feb 28, 2026 · Original filing |
| 5 | SMALLCAP World Fund Inc SMALLCAP World Fund Inc | 4,458,145 | 334.8M $ | 0.41 % | as of Mar 31, 2026 · Original filing |
| 6 | VANGUARD HEALTH CARE FUND VANGUARD SPECIALIZED FUNDS | 3,803,181 | 284.3M $ | 0.77 % | as of Apr 30, 2026 · Original filing |
| 7 | VANGUARD SMALL-CAP INDEX FUND VANGUARD INDEX FUNDS | 3,618,441 | 271.7M $ | 0.17 % | as of Mar 31, 2026 · Original filing |
| 8 | T. Rowe Price Mid-Cap Growth Fund, Inc. T. ROWE PRICE MID-CAP GROWTH FUND, INC. | 2,760,687 | 207.3M $ | 0.92 % | as of Mar 31, 2026 · Original filing |
| 9 | Fidelity Growth Company K6 Fund Fidelity Mt. Vernon Street Trust | 2,315,503 | 187.9M $ | 0.81 % | as of Feb 28, 2026 · Original filing |
| 10 | Fidelity Series Growth Company Fund Fidelity Mt. Vernon Street Trust | 2,096,577 | 170.1M $ | 0.80 % | as of Feb 28, 2026 · Original filing |
| 11 | VANGUARD SMALL-CAP GROWTH INDEX FUND VANGUARD INDEX FUNDS | 2,025,434 | 152.1M $ | 0.39 % | as of Mar 31, 2026 · Original filing |
| 12 | VANGUARD EXTENDED MARKET INDEX FUND VANGUARD INDEX FUNDS | 1,808,172 | 135.8M $ | 0.17 % | as of Mar 31, 2026 · Original filing |
| 13 | Tweedy, Browne International Value Fund Tweedy, Browne Fund Inc. | 1,743,125 | 130.9M $ | 3.17 % | as of Mar 31, 2026 · Original filing |
| 14 | Growth Fund AMERICAN FUNDS INSURANCE SERIES | 1,674,900 | 125.8M $ | 0.25 % | as of Mar 31, 2026 · Original filing |
| 15 | iShares Biotechnology ETF iShares Trust | 1,205,549 | 90.5M $ | 1.11 % | as of Mar 31, 2026 · Original filing |
| 16 | VANGUARD EXPLORER FUND VANGUARD EXPLORER FUND | 1,195,911 | 89.4M $ | 0.41 % | as of Apr 30, 2026 · Original filing |
| 17 | State Street(R) SPDR(R) S&P(R) Biotech ETF SPDR SERIES TRUST | 1,132,906 | 85.1M $ | 1.14 % | as of Mar 31, 2026 · Original filing |
| 18 | Capital Group Growth ETF Capital Group Growth ETF | 1,054,074 | 85.5M $ | 0.42 % | as of Feb 28, 2026 · Original filing |
| 19 | iShares Russell Mid-Cap Growth ETF iShares Trust | 987,917 | 74.2M $ | 0.40 % | as of Mar 31, 2026 · Original filing |
| 20 | Select Fund American Century Mutual Funds, Inc. | 962,000 | 71.9M $ | 1.12 % | as of Apr 30, 2026 · Original filing |
| 21 | T. Rowe Price Health Sciences Fund, Inc. T. ROWE PRICE HEALTH SCIENCES FUND, INC. | 882,823 | 66.3M $ | 0.61 % | as of Mar 31, 2026 · Original filing |
| 22 | Fidelity Extended Market Index Fund Fidelity Concord Street Trust | 847,073 | 68.7M $ | 0.17 % | as of Feb 28, 2026 · Original filing |
| 23 | JPMorgan Mid Cap Growth Fund JPMorgan Trust II | 806,672 | 60.6M $ | 0.53 % | as of Mar 31, 2026 · Original filing |
| 24 | Franklin Dynatech Fund Franklin Custodian Funds | 800,000 | 60.1M $ | 0.24 % | as of Mar 31, 2026 · Original filing |
| 25 | Schwab U.S. Small-Cap ETF SCHWAB STRATEGIC TRUST | 786,080 | 63.8M $ | 0.31 % | as of Feb 28, 2026 · Original filing |
| 26 | Nomura Mid Cap Growth Fund IVY FUNDS | 606,560 | 45.5M $ | 1.52 % | as of Mar 31, 2026 · Original filing |
| 27 | iShares Russell Mid-Cap ETF iShares Trust | 603,764 | 45.3M $ | 0.09 % | as of Mar 31, 2026 · Original filing |
| 28 | iShares Russell 1000 Growth ETF iShares Trust | 592,553 | 44.5M $ | 0.04 % | as of Mar 31, 2026 · Original filing |
| 29 | Fidelity Mid Cap Index Fund Fidelity Salem Street Trust | 585,766 | 43.8M $ | 0.09 % | as of Apr 30, 2026 · Original filing |
| 30 | T. Rowe Price New Horizons Fund, Inc. T. ROWE PRICE NEW HORIZONS FUND, INC. | 578,082 | 43.4M $ | 0.34 % | as of Mar 31, 2026 · Original filing |
| 31 | Eventide Healthcare & Life Sciences Fund MUTUAL FUND SERIES TRUST | 575,000 | 43.2M $ | 2.72 % | as of Mar 31, 2026 · Original filing |
| 32 | JNL/T. Rowe Price Mid-Cap Growth Fund JNL Series Trust | 492,756 | 37M $ | 0.92 % | as of Mar 31, 2026 · Original filing |
| 33 | Select Biotechnology Portfolio Fidelity Select Portfolios | 476,377 | 38.7M $ | 0.72 % | as of Feb 28, 2026 · Original filing |
| 34 | VANGUARD HEALTH CARE INDEX FUND VANGUARD WORLD FUND | 455,079 | 36.9M $ | 0.18 % | as of Feb 28, 2026 · Original filing |
| 35 | Schwab U.S. Mid-Cap ETF SCHWAB STRATEGIC TRUST | 438,078 | 35.6M $ | 0.26 % | as of Feb 28, 2026 · Original filing |
| 36 | Fidelity SAI Small-Mid Cap Momentum Index Fund Fidelity Salem Street Trust | 429,251 | 32.1M $ | 0.75 % | as of Apr 30, 2026 · Original filing |
| 37 | Artisan International Small-Mid Fund Artisan Partners Funds Inc. | 390,363 | 29.3M $ | 1.10 % | as of Mar 31, 2026 · Original filing |
| 38 | Global Growth Fund AMERICAN FUNDS INSURANCE SERIES | 388,000 | 29.1M $ | 0.34 % | as of Mar 31, 2026 · Original filing |
| 39 | VANGUARD STRATEGIC EQUITY FUND VANGUARD HORIZON FUNDS | 379,257 | 28.5M $ | 0.28 % | as of Mar 31, 2026 · Original filing |
| 40 | T. Rowe Price Institutional Mid-Cap Equity Growth Fund T. Rowe Price Equity Funds, Inc. | 334,595 | 25.1M $ | 0.91 % | as of Mar 31, 2026 · Original filing |
| 41 | Small Cap Growth Fund American Century Mutual Funds, Inc. | 311,872 | 23.3M $ | 0.46 % | as of Apr 30, 2026 · Original filing |
| 42 | MFS New Discovery Fund MFS SERIES TRUST I | 306,440 | 24.9M $ | 1.19 % | as of Feb 28, 2026 · Original filing |
| 43 | Fidelity Total Market Index Fund Fidelity Concord Street Trust | 304,119 | 24.7M $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 44 | ARK Genomic Revolution ETF ARK ETF Trust | 288,230 | 21.5M $ | 1.74 % | as of Apr 30, 2026 · Original filing |
| 45 | Artisan Small Cap Fund Artisan Partners Funds Inc. | 280,144 | 21M $ | 2.36 % | as of Mar 31, 2026 · Original filing |
| 46 | Capital Group U.S. Small and Mid Cap ETF Capital Group Equity ETF Trust I | 272,278 | 22.1M $ | 1.32 % | as of Feb 28, 2026 · Original filing |
| 47 | Strategic Advisers U.S. Total Stock Fund Fidelity Rutland Square Trust II | 269,755 | 21.9M $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 48 | MassMutual Mid Cap Growth Fund MASSMUTUAL SELECT FUNDS | 254,240 | 19.1M $ | 0.69 % | as of Mar 31, 2026 · Original filing |
| 49 | VANGUARD RUSSELL 1000 GROWTH INDEX FUND VANGUARD SCOTTSDALE FUNDS | 242,155 | 19.7M $ | 0.04 % | as of Feb 28, 2026 · Original filing |
| 50 | Fidelity Series Total Market Index Fund Fidelity Concord Street Trust | 240,112 | 19.5M $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 51 | Empower T. Rowe Price Mid Cap Growth Fund EMPOWER FUNDS, INC. | 239,848 | 18M $ | 0.95 % | as of Mar 31, 2026 · Original filing |
| 52 | College Retirement Equities Fund - Total Global Stock Account College Retirement Equities Fund | 230,687 | 17.3M $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 53 | T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC. | 227,425 | 17.1M $ | 0.21 % | as of Mar 31, 2026 · Original filing |
| 54 | JNL/JPMorgan MidCap Growth Fund JNL Series Trust | 221,855 | 16.7M $ | 0.53 % | as of Mar 31, 2026 · Original filing |
| 55 | T. Rowe Price Diversified Mid-Cap Growth Fund, Inc. T. ROWE PRICE DIVERSIFIED MID-CAP GROWTH FUND, INC. | 221,400 | 16.6M $ | 0.39 % | as of Mar 31, 2026 · Original filing |
| 56 | Invesco Main Street Mid Cap Fund AIM Growth Series (Invesco Growth Series) | 209,750 | 15.8M $ | 0.67 % | as of Mar 31, 2026 · Original filing |
| 57 | Fidelity Large Cap Growth Index Fund Fidelity Salem Street Trust | 208,977 | 15.6M $ | 0.04 % | as of Apr 30, 2026 · Original filing |
| 58 | VANGUARD STRATEGIC SMALL-CAP EQUITY FUND VANGUARD HORIZON FUNDS | 206,933 | 15.5M $ | 0.63 % | as of Mar 31, 2026 · Original filing |
| 59 | iShares Core S&P Total U.S. Stock Market ETF iShares Trust | 206,338 | 15.5M $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 60 | Franklin Biotechnology Discovery Fund Franklin Strategic Series | 205,400 | 15.4M $ | 1.48 % | as of Apr 30, 2026 · Original filing |
| 61 | MFS New Discovery Value Fund MFS SERIES TRUST XIII | 204,801 | 16.6M $ | 0.61 % | as of Feb 28, 2026 · Original filing |
| 62 | First Trust Health Care AlphaDEX Fund First Trust Exchange-Traded AlphaDEX Fund | 201,598 | 15.1M $ | 1.72 % | as of Apr 30, 2026 · Original filing |
| 63 | Goldman Sachs Small/Mid Cap Growth Fund Goldman Sachs Trust | 187,207 | 15.2M $ | 1.24 % | as of Feb 28, 2026 · Original filing |
| 64 | Artisan Mid Cap Fund Artisan Partners Funds Inc. | 186,456 | 14M $ | 0.47 % | as of Mar 31, 2026 · Original filing |
| 65 | Fidelity Mid Cap Growth Index Fund Fidelity Salem Street Trust | 179,499 | 13.5M $ | 0.40 % | as of Mar 31, 2026 · Original filing |
| 66 | BlackRock Health Sciences Opportunities Portfolio BlackRock Funds | 170,008 | 13.8M $ | 0.21 % | as of Feb 27, 2026 · Original filing |
| 67 | Tweedy, Browne Value Fund Tweedy, Browne Fund Inc. | 169,635 | 12.7M $ | 2.79 % | as of Mar 31, 2026 · Original filing |
| 68 | JPMorgan Large Cap Value Fund JPMorgan Trust II | 168,569 | 12.7M $ | 0.26 % | as of Mar 31, 2026 · Original filing |
| 69 | Franklin Small-Mid Cap Growth Fund Franklin Strategic Series | 167,060 | 12.5M $ | 0.35 % | as of Apr 30, 2026 · Original filing |
| 70 | VANGUARD TAX-MANAGED CAPITAL APPRECIATION FUND VANGUARD TAX-MANAGED FUNDS | 164,671 | 12.4M $ | 0.05 % | as of Mar 31, 2026 · Original filing |
| 71 | Handelsbanken Hälsovård Tema Handelsbanken Fonder AB | 154,000 | 110.2M SEK | 0.50 % | as of Mar 31, 2026 · Original filing |
| 72 | Bridge Builder Small/Mid Cap Growth Fund Bridge Builder Trust | 153,612 | 11.5M $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 73 | Invesco Small Cap Growth Fund AIM Growth Series (Invesco Growth Series) | 152,122 | 11.4M $ | 0.74 % | as of Mar 31, 2026 · Original filing |
| 74 | JNL/Invesco Small Cap Growth Fund JNL Series Trust | 150,988 | 11.3M $ | 0.73 % | as of Mar 31, 2026 · Original filing |
| 75 | Nuveen ESG Small-Cap ETF NuShares ETF Trust | 150,398 | 11.2M $ | 0.87 % | as of Apr 30, 2026 · Original filing |
| 76 | Columbia Acorn Fund COLUMBIA ACORN TRUST | 148,670 | 11.2M $ | 0.50 % | as of Mar 31, 2026 · Original filing |
| 77 | Invesco RAFI US 1500 Small-Mid ETF Invesco Exchange-Traded Fund Trust | 140,692 | 10.5M $ | 0.37 % | as of Apr 30, 2026 · Original filing |
| 78 | VANGUARD TOTAL WORLD STOCK INDEX FUND VANGUARD INTERNATIONAL EQUITY INDEX FUNDS | 138,602 | 10.4M $ | 0.01 % | as of Apr 30, 2026 · Original filing |
| 79 | Nuveen Equity Index Fund TIAA-CREF Funds | 129,890 | 9.7M $ | 0.02 % | as of Apr 30, 2026 · Original filing |
| 80 | T. Rowe Price Mid Cap Growth Portfolio Brighthouse Funds Trust I | 127,690 | 9.6M $ | 0.91 % | as of Mar 31, 2026 · Original filing |
| 81 | iShares U.S. Small-Cap Equity Factor ETF iShares Trust | 121,095 | 9.1M $ | 0.25 % | as of Apr 30, 2026 · Original filing |
| 82 | iShares U.S. Equity Factor Rotation Active ETF BlackRock ETF Trust | 118,150 | 8.8M $ | 0.03 % | as of Apr 30, 2026 · Original filing |
| 83 | Goldman Sachs Mid Cap Growth Fund Goldman Sachs Trust | 116,280 | 9.4M $ | 0.96 % | as of Feb 28, 2026 · Original filing |
| 84 | SEB Läkemedelsfond SEB Funds AB | 114,334 | 81.8M SEK | 0.51 % | as of Mar 31, 2026 · Original filing |
| 85 | JPMorgan Mid Cap Equity Fund JPMorgan Trust I | 111,845 | 8.4M $ | 0.15 % | as of Mar 31, 2026 · Original filing |
| 86 | iShares Russell 1000 ETF iShares Trust | 110,042 | 8.3M $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 87 | Invesco Health Care Fund AIM Investment Funds (Invesco Investment Funds) | 107,312 | 8M $ | 0.71 % | as of Apr 30, 2026 · Original filing |
| 88 | Fidelity SAI U.S. Momentum Index Fund Fidelity Salem Street Trust | 106,308 | 7.9M $ | 0.10 % | as of Apr 30, 2026 · Original filing |
| 89 | SMALL COMPANY GROWTH PORTFOLIO VANGUARD VARIABLE INSURANCE FUNDS | 102,433 | 7.7M $ | 0.56 % | as of Mar 31, 2026 · Original filing |
| 90 | AMG TimesSquare Mid Cap Growth Fund AMG Funds | 101,884 | 7.7M $ | 0.51 % | as of Mar 31, 2026 · Original filing |
| 91 | JPMorgan Active Value ETF J.P. Morgan Exchange-Traded Fund Trust | 101,151 | 7.6M $ | 0.13 % | as of Mar 31, 2026 · Original filing |
| 92 | Large Cap Index Master Portfolio Master Investment Portfolio | 97,359 | 7.3M $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 93 | Fidelity Nasdaq Composite Index Fund Fidelity Concord Street Trust | 96,289 | 7.8M $ | 0.03 % | as of Feb 28, 2026 · Original filing |
| 94 | Schwab Total Stock Market Index Fund SCHWAB CAPITAL TRUST | 95,438 | 7.1M $ | 0.02 % | as of Apr 30, 2026 · Original filing |
| 95 | Schwab U.S. Broad Market ETF SCHWAB STRATEGIC TRUST | 95,236 | 7.7M $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 96 | MFS New Discovery Series MFS VARIABLE INSURANCE TRUST | 94,701 | 7.1M $ | 1.00 % | as of Mar 31, 2026 · Original filing |
| 97 | Mid Cap Growth Fund John Hancock Investment Trust | 94,101 | 7.1M $ | 0.62 % | as of Mar 31, 2026 · Original filing |
| 98 | Nuveen Large Cap Growth Index Fund TIAA-CREF Funds | 90,571 | 6.8M $ | 0.04 % | as of Apr 30, 2026 · Original filing |
| 99 | VANGUARD BALANCED INDEX FUND VANGUARD VALLEY FORGE FUNDS | 88,570 | 6.7M $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 100 | Bridge Builder Small/Mid Cap Value Fund Bridge Builder Trust | 87,365 | 6.6M $ | 0.07 % | as of Mar 31, 2026 · Original filing |
Institutional managers
483 managers declare this company to the SEC (Form 13F). These positions are not counted in the totals above: a manager and its own funds file separately.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 24,556,637 | 1.8B $ | as of Mar 31, 2026 |
| Capital World Investors | 21,186,369 | 1.6B $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 10,442,476 | 784.1M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 6,391,816 | 480M $ | as of Mar 31, 2026 |
| TWO SIGMA INVESTMENTS, LP | 5,857,629 | 439.8M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,984,332 | 305.2M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 3,995,564 | 300M $ | as of Mar 31, 2026 |
| ROYAL BANK OF CANADA | 3,801,815 | 285.5M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 2,363,567 | 171.4M $ | as of Mar 31, 2026 |
| Tweedy, Browne Co LLC | 2,275,625 | 170.9M $ | as of Mar 31, 2026 |
| Artisan Partners Limited Partnership | 2,058,308 | 154.6M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 2,047,727 | 153.8M $ | as of Mar 31, 2026 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,979,669 | 148.7M $ | as of Mar 31, 2026 |
| Deep Track Capital, LP | 1,950,000 | 146.4M $ | as of Mar 31, 2026 |
| Bellevue Group AG | 1,818,665 | 136.6M $ | as of Mar 31, 2026 |
| GOLDMAN SACHS GROUP INC | 1,699,847 | 127.6M $ | as of Mar 31, 2026 |
| AMERICAN CENTURY COMPANIES INC | 1,663,803 | 124.9M $ | as of Mar 31, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,583,266 | 118.9M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 1,575,023 | 118.3M $ | as of Mar 31, 2026 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,475,632 | 110.8M $ | as of Mar 31, 2026 |
| Pictet Asset Management Holding SA | 1,434,995 | 107.1M $ | as of Mar 31, 2026 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,404,033 | 105.4M $ | as of Mar 31, 2026 |
| Invesco Ltd. | 1,277,358 | 95.9M $ | as of Mar 31, 2026 |
| MILLENNIUM MANAGEMENT LLC | 1,051,506 | 79M $ | as of Mar 31, 2026 |
| MORGAN STANLEY | 1,026,509 | 77.1M $ | as of Mar 31, 2026 |