Funds holding Ionis Pharmaceuticals Inc
431 funds declare a position · 100 ETFs and 331 other funds · 6.6B $· 346.9M SEK· 4M € · US4622221004
Each line carries its report date.
| Rank | Fund | Shares | Value | Weight | |
|---|---|---|---|---|---|
| 101 | Fidelity ZERO Total Market Index Fund Fidelity Concord Street Trust | 84,338 | 6.3M $ | 0.02 % | as of Apr 30, 2026 · Original filing |
| 102 | Invesco Biotechnology & Genome ETF Invesco Exchange-Traded Fund Trust | 82,240 | 6.1M $ | 2.49 % | as of Apr 30, 2026 · Original filing |
| 103 | AMG GW&K Small/Mid Cap Core Fund AMG Funds | 81,942 | 6.2M $ | 0.86 % | as of Mar 31, 2026 · Original filing |
| 104 | iShares U.S. Healthcare ETF iShares Trust | 81,222 | 6.1M $ | 0.22 % | as of Apr 30, 2026 · Original filing |
| 105 | THE HARTFORD HEALTHCARE FUND HARTFORD MUTUAL FUNDS, INC | 78,893 | 5.9M $ | 0.81 % | as of Apr 30, 2026 · Original filing |
| 106 | VANGUARD U.S. MOMENTUM FACTOR ETF VANGUARD WELLINGTON FUND | 78,563 | 6.4M $ | 0.46 % | as of Feb 28, 2026 · Original filing |
| 107 | Invesco Small Cap Growth Portfolio Brighthouse Funds Trust I | 76,854 | 5.8M $ | 0.73 % | as of Mar 31, 2026 · Original filing |
| 108 | VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND VANGUARD INSTITUTIONAL INDEX FUNDS | 75,679 | 5.7M $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 109 | Invesco NASDAQ Next Gen 100 ETF Invesco Exchange-Traded Fund Trust II | 72,207 | 5.9M $ | 0.65 % | as of Feb 28, 2026 · Original filing |
| 110 | Fidelity Small-Mid Multifactor ETF Fidelity Covington Trust | 71,810 | 5.4M $ | 0.23 % | as of Apr 30, 2026 · Original filing |
| 111 | RBC Global Opportunities Fund RBC Funds Trust | 71,300 | 5.4M $ | 1.25 % | as of Mar 31, 2026 · Original filing |
| 112 | Fidelity MSCI Health Care Index ETF FIDELITY COVINGTON TRUST | 70,978 | 5.3M $ | 0.19 % | as of Apr 30, 2026 · Original filing |
| 113 | HealthInvest Sustainable Healthcare Atle Fund Management AB | 69,349 | 49.3M SEK | 1.55 % | as of Mar 31, 2026 · Original filing |
| 114 | Mid Cap Growth Stock Portfolio NORTHWESTERN MUTUAL SERIES FUND INC | 68,528 | 5.1M $ | 0.54 % | as of Mar 31, 2026 · Original filing |
| 115 | iShares ESG Aware MSCI USA Small-Cap ETF iShares Trust | 68,097 | 5.5M $ | 0.24 % | as of Feb 28, 2026 · Original filing |
| 116 | Nomura VIP Mid Cap Growth Series Ivy Variable Insurance Portfolios | 68,019 | 5.1M $ | 1.51 % | as of Mar 31, 2026 · Original filing |
| 117 | Direxion Daily S&P Biotech Bull 3X Shares Direxion Shares ETF Trust | 64,911 | 4.9M $ | 0.94 % | as of Apr 30, 2026 · Original filing |
| 118 | LVIP T. Rowe Price Structured Mid-Cap Growth Fund LINCOLN VARIABLE INSURANCE PRODUCTS TRUST | 63,862 | 4.8M $ | 0.37 % | as of Mar 31, 2026 · Original filing |
| 119 | Bridge Builder Tax Managed Small/Mid Cap Fund Bridge Builder Trust | 63,256 | 4.7M $ | 0.16 % | as of Mar 31, 2026 · Original filing |
| 120 | JNL/Mellon Healthcare Sector Fund JNL Series Trust | 63,225 | 4.7M $ | 0.19 % | as of Mar 31, 2026 · Original filing |
| 121 | THE HARTFORD SMALL COMPANY FUND HARTFORD MUTUAL FUNDS, INC | 62,803 | 4.7M $ | 0.71 % | as of Apr 30, 2026 · Original filing |
| 122 | JPMorgan U.S. Momentum Factor ETF J.P. Morgan Exchange-Traded Fund Trust | 62,392 | 4.7M $ | 0.21 % | as of Apr 30, 2026 · Original filing |
| 123 | Mid Cap Growth Portfolio NEUBERGER BERMAN ADVISERS MANAGEMENT TRUST | 61,572 | 4.6M $ | 0.92 % | as of Mar 31, 2026 · Original filing |
| 124 | Neuberger Mid Cap Growth Fund NEUBERGER BERMAN EQUITY FUNDS | 61,410 | 5M $ | 0.25 % | as of Feb 28, 2026 · Original filing |
| 125 | JPMorgan BetaBuilders U.S. Mid Cap Equity ETF J.P. Morgan Exchange-Traded Fund Trust | 60,227 | 4.5M $ | 0.22 % | as of Apr 30, 2026 · Original filing |
| 126 | Fidelity Momentum Factor ETF Fidelity Covington Trust | 60,169 | 4.5M $ | 0.53 % | as of Apr 30, 2026 · Original filing |
| 127 | Handelsbanken Global Småbolag Index Criteria Handelsbanken Fonder AB | 59,911 | 42.9M SEK | 0.15 % | as of Mar 31, 2026 · Original filing |
| 128 | T. Rowe Price Small-Mid Cap ETF T. Rowe Price Exchange-Traded Funds, Inc. | 59,742 | 4.5M $ | 0.29 % | as of Mar 31, 2026 · Original filing |
| 129 | iShares Russell 2500 ETF iShares Trust | 59,253 | 4.4M $ | 0.17 % | as of Mar 31, 2026 · Original filing |
| 130 | FundX Future Fund Opportunities ETF FundX Investment Trust | 58,732 | 4.4M $ | 2.24 % | as of Mar 31, 2026 · Original filing |
| 131 | Fidelity ZERO Extended Market Index Fund Fidelity Concord Street Trust | 57,004 | 4.3M $ | 0.18 % | as of Apr 30, 2026 · Original filing |
| 132 | SA JPMorgan Mid-Cap Growth Portfolio SUNAMERICA SERIES TRUST | 56,542 | 4.2M $ | 0.64 % | as of Apr 30, 2026 · Original filing |
| 133 | American Funds U.S. Small & Mid Cap Equity Fund American Funds U.S. Small & Mid Cap Equity Fund | 56,370 | 4.6M $ | 1.18 % | as of Feb 28, 2026 · Original filing |
| 134 | STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO STATE STREET INSTITUTIONAL INVESTMENT TRUST | 56,321 | 4.2M $ | 0.16 % | as of Mar 31, 2026 · Original filing |
| 135 | HealthInvest Small & Mid Cap Healthcare Atle Fund Management AB | 55,818 | 39.7M SEK | 3.98 % | as of Mar 31, 2026 · Original filing |
| 136 | T. Rowe Price Health Sciences Portfolio T. ROWE PRICE EQUITY SERIES, INC. | 55,343 | 4.2M $ | 0.63 % | as of Mar 31, 2026 · Original filing |
| 137 | John Hancock Multifactor Mid Cap ETF John Hancock Exchange-Traded Fund Trust | 54,344 | 4.1M $ | 0.08 % | as of Mar 31, 2026 · Original filing |
| 138 | T. Rowe Price Integrated U.S. Small-Mid Cap Core Equity Fund T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC. | 53,729 | 4M $ | 0.28 % | as of Mar 31, 2026 · Original filing |
| 139 | T. Rowe Price Mid-Cap Growth Portfolio T. ROWE PRICE EQUITY SERIES, INC. | 53,379 | 4M $ | 0.93 % | as of Mar 31, 2026 · Original filing |
| 140 | Mid Cap Growth Trust John Hancock Variable Insurance Trust | 53,020 | 4M $ | 0.62 % | as of Mar 31, 2026 · Original filing |
| 141 | Small Cap Growth Stock Portfolio NORTHWESTERN MUTUAL SERIES FUND INC | 52,863 | 4M $ | 0.54 % | as of Mar 31, 2026 · Original filing |
| 142 | Mercer US Small/Mid Cap Equity Fund Mercer Funds | 52,526 | 3.9M $ | 0.23 % | as of Mar 31, 2026 · Original filing |
| 143 | Schwab 1000 Index Fund SCHWAB INVESTMENTS | 51,551 | 3.9M $ | 0.02 % | as of Apr 30, 2026 · Original filing |
| 144 | First Trust BuyWrite Income ETF First Trust Exchange-Traded Fund VI | 50,889 | 3.8M $ | 0.19 % | as of Mar 31, 2026 · Original filing |
| 145 | Tweedy, Browne International Value Fund II - Currency Unhedged Tweedy, Browne Fund Inc. | 50,402 | 3.8M $ | 2.41 % | as of Mar 31, 2026 · Original filing |
| 146 | iShares Morningstar Small-Cap Growth ETF iShares Trust | 46,901 | 3.5M $ | 0.37 % | as of Apr 30, 2026 · Original filing |
| 147 | Dimensional U.S. Equity Market ETF Dimensional ETF Trust | 46,391 | 3.5M $ | 0.02 % | as of Apr 30, 2026 · Original filing |
| 148 | Baron Health Care Fund BARON SELECT FUNDS | 45,000 | 3.4M $ | 2.81 % | as of Mar 31, 2026 · Original filing |
| 149 | MML Mid Cap Growth Fund MML SERIES INVESTMENT FUND | 43,861 | 3.3M $ | 0.94 % | as of Mar 31, 2026 · Original filing |
| 150 | VY(R) T. ROWE PRICE DIVERSIFIED MID CAP GROWTH PORTFOLIO Voya Partners Inc | 42,530 | 3.2M $ | 0.38 % | as of Mar 31, 2026 · Original filing |
| 151 | iShares Russell 3000 ETF iShares Trust | 42,354 | 3.2M $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 152 | VictoryShares US Small Mid Cap Value Momentum ETF Victory Portfolios II | 41,805 | 3.1M $ | 0.22 % | as of Mar 31, 2026 · Original filing |
| 153 | EQ/JPMorgan Value Opportunities Portfolio EQ Advisors Trust | 41,234 | 3.1M $ | 0.25 % | as of Mar 31, 2026 · Original filing |
| 154 | BlackRock Advantage Small Cap Core Fund BlackRock Funds | 41,061 | 3.3M $ | 0.07 % | as of Feb 27, 2026 · Original filing |
| 155 | Small-Cap Growth Portfolio PACIFIC SELECT FUND | 39,949 | 3M $ | 0.68 % | as of Mar 31, 2026 · Original filing |
| 156 | Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 38,394 | 2.9M $ | 2.37 % | as of Apr 30, 2026 · Original filing |
| 157 | HARTFORD SMALL CAP GROWTH HLS FUND HARTFORD SERIES FUND INC | 38,032 | 2.9M $ | 0.54 % | as of Mar 31, 2026 · Original filing |
| 158 | AMG GW&K Small Cap Growth Fund AMG Funds IV | 37,684 | 2.8M $ | 1.35 % | as of Apr 30, 2026 · Original filing |
| 159 | Goldman Sachs Small Cap Growth Fund Goldman Sachs Trust | 37,118 | 3M $ | 0.71 % | as of Feb 28, 2026 · Original filing |
| 160 | Fidelity Nasdaq Composite Index ETF Fidelity Commonwealth Trust | 36,650 | 3M $ | 0.03 % | as of Feb 28, 2026 · Original filing |
| 161 | First Trust Mid Cap Growth AlphaDEX Fund First Trust Exchange-Traded AlphaDEX Fund | 36,525 | 2.7M $ | 0.53 % | as of Apr 30, 2026 · Original filing |
| 162 | Blackstone Alternative Multi-Strategy Fund Blackstone Alternative Investment Funds | 36,300 | 2.7M $ | 0.08 % | as of Mar 31, 2026 · Original filing |
| 163 | First Trust Mid Cap Core AlphaDEX Fund First Trust Exchange-Traded AlphaDEX Fund | 36,263 | 2.7M $ | 0.20 % | as of Apr 30, 2026 · Original filing |
| 164 | ALGER WEATHERBIE SPECIALIZED GROWTH FUND ALGER FUNDS | 35,938 | 2.7M $ | 0.96 % | as of Apr 30, 2026 · Original filing |
| 165 | Small Cap Growth Fund VALIC Co I | 35,875 | 2.9M $ | 0.54 % | as of Feb 28, 2026 · Original filing |
| 166 | VANGUARD ESG U.S. STOCK ETF VANGUARD WORLD FUND | 34,909 | 2.8M $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 167 | Tweedy, Browne Insider + Value ETF RBB Fund Trust | 33,941 | 2.8M $ | 0.92 % | as of Feb 28, 2026 · Original filing |
| 168 | Dimensional U.S. Core Equity 2 ETF Dimensional ETF Trust | 32,429 | 2.4M $ | 0.01 % | as of Apr 30, 2026 · Original filing |
| 169 | Swedbank Robur Healthcare Swedbank Robur Fonder AB | 32,253 | 23.1M SEK | 0.16 % | as of Mar 31, 2026 · Original filing |
| 170 | Fidelity OTC Portfolio Fidelity Securities Fund | 31,362 | 2.3M $ | 0.01 % | as of Apr 30, 2026 · Original filing |
| 171 | Schwab U.S. Mid-Cap Index Fund SCHWAB CAPITAL TRUST | 30,271 | 2.3M $ | 0.09 % | as of Apr 30, 2026 · Original filing |
| 172 | T.Rowe Price Small Cap Growth Portfolio Brighthouse Funds Trust II | 30,107 | 2.3M $ | 0.21 % | as of Mar 31, 2026 · Original filing |
| 173 | State Street(R) SPDR(R) S&P Kensho New Economies Composite ETF SPDR SERIES TRUST | 29,912 | 2.2M $ | 0.10 % | as of Mar 31, 2026 · Original filing |
| 174 | Buffalo Small Cap Growth Fund Buffalo Funds | 29,105 | 2.2M $ | 0.56 % | as of Mar 31, 2026 · Original filing |
| 175 | First Trust US Equity Opportunities ETF First Trust Exchange-Traded Fund | 28,905 | 2.2M $ | 0.19 % | as of Mar 31, 2026 · Original filing |
| 176 | Nationwide Fundamental All Cap Equity Portfolio Nationwide Mutual Funds | 28,823 | 2.2M $ | 0.14 % | as of Apr 30, 2026 · Original filing |
| 177 | TIFF MULTI-ASSET FUND TIFF Investment Program | 28,724 | 2.2M $ | 0.16 % | as of Mar 31, 2026 · Original filing |
| 178 | Bridge Builder Large Cap Growth Fund Bridge Builder Trust | 28,705 | 2.2M $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 179 | Columbia Variable Portfolio - Acorn Fund COLUMBIA FUNDS VARIABLE SERIES TRUST | 28,657 | 2.2M $ | 0.50 % | as of Mar 31, 2026 · Original filing |
| 180 | VanEck Morningstar SMID Moat ETF VanEck ETF Trust | 28,058 | 2.1M $ | 0.66 % | as of Mar 31, 2026 · Original filing |
| 181 | iShares Russell 1000 Value ETF iShares Trust | 27,501 | 2.1M $ | 0.00 % | as of Mar 31, 2026 · Original filing |
| 182 | iShares Russell Mid-Cap Index Fund BlackRock Funds | 27,369 | 2M $ | 0.09 % | as of Apr 30, 2026 · Original filing |
| 183 | SA Invesco Growth Opportunities Portfolio SUNAMERICA SERIES TRUST | 26,411 | 2M $ | 0.65 % | as of Apr 30, 2026 · Original filing |
| 184 | VANGUARD RUSSELL 1000 INDEX FUND VANGUARD SCOTTSDALE FUNDS | 26,180 | 2.1M $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 185 | BlackRock Advantage SMID Cap Fund, Inc. BlackRock Advantage SMID Cap Fund, Inc. | 25,722 | 1.9M $ | 0.26 % | as of Mar 31, 2026 · Original filing |
| 186 | VANGUARD GROWTH AND INCOME FUND VANGUARD QUANTITATIVE FUNDS | 25,200 | 1.9M $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 187 | BNY Mellon US Mid Cap Core Equity ETF BNY Mellon ETF Trust | 25,160 | 1.9M $ | 0.30 % | as of Apr 30, 2026 · Original filing |
| 188 | iShares Russell Small/Mid-Cap Index Fund BlackRock Funds | 24,973 | 1.9M $ | 0.15 % | as of Apr 30, 2026 · Original filing |
| 189 | Biotechnology Fund Rydex Series Funds | 24,870 | 1.9M $ | 1.38 % | as of Mar 31, 2026 · Original filing |
| 190 | EQ/Common Stock Index Portfolio EQ Advisors Trust | 24,800 | 1.9M $ | 0.03 % | as of Mar 31, 2026 · Original filing |
| 191 | SIIT EXTENDED MARKET INDEX FUND SEI INSTITUTIONAL INVESTMENTS TRUST | 24,394 | 2M $ | 0.16 % | as of Feb 28, 2026 · Original filing |
| 192 | Dimensional US Core Equity Market ETF Dimensional ETF Trust | 24,341 | 1.8M $ | 0.02 % | as of Apr 30, 2026 · Original filing |
| 193 | Fidelity Flex Mid Cap Index Fund Fidelity Salem Street Trust | 23,505 | 1.8M $ | 0.29 % | as of Apr 30, 2026 · Original filing |
| 194 | T. Rowe Price Extended Equity Market Index Fund T. ROWE PRICE INDEX TRUST, INC. | 22,644 | 1.7M $ | 0.17 % | as of Mar 31, 2026 · Original filing |
| 195 | Schwab U.S. Large-Cap Growth Index Fund SCHWAB CAPITAL TRUST | 22,383 | 1.7M $ | 0.04 % | as of Apr 30, 2026 · Original filing |
| 196 | Penn Series Mid Cap Growth Fund Penn Series Funds Inc | 21,502 | 1.6M $ | 1.51 % | as of Mar 31, 2026 · Original filing |
| 197 | Nuveen Small/Mid Cap Growth Opportunities Fund Nuveen Investment Funds, Inc. | 21,329 | 1.6M $ | 0.94 % | as of Apr 30, 2026 · Original filing |
| 198 | HARTFORD SMALL COMPANY HLS FUND HARTFORD SERIES FUND INC | 20,285 | 1.5M $ | 0.39 % | as of Mar 31, 2026 · Original filing |
| 199 | BIOTECHNOLOGY ULTRASECTOR PROFUND ProFunds | 20,089 | 1.5M $ | 0.82 % | as of Apr 30, 2026 · Original filing |
| 200 | Victory RS Select Growth Fund Victory Portfolios | 20,070 | 1.5M $ | 1.98 % | as of Mar 31, 2026 · Original filing |
Institutional managers
483 managers declare this company to the SEC (Form 13F). These positions are not counted in the totals above: a manager and its own funds file separately.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 24,556,637 | 1.8B $ | as of Mar 31, 2026 |
| Capital World Investors | 21,186,369 | 1.6B $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 10,442,476 | 784.1M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 6,391,816 | 480M $ | as of Mar 31, 2026 |
| TWO SIGMA INVESTMENTS, LP | 5,857,629 | 439.8M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,984,332 | 305.2M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 3,995,564 | 300M $ | as of Mar 31, 2026 |
| ROYAL BANK OF CANADA | 3,801,815 | 285.5M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 2,363,567 | 171.4M $ | as of Mar 31, 2026 |
| Tweedy, Browne Co LLC | 2,275,625 | 170.9M $ | as of Mar 31, 2026 |
| Artisan Partners Limited Partnership | 2,058,308 | 154.6M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 2,047,727 | 153.8M $ | as of Mar 31, 2026 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,979,669 | 148.7M $ | as of Mar 31, 2026 |
| Deep Track Capital, LP | 1,950,000 | 146.4M $ | as of Mar 31, 2026 |
| Bellevue Group AG | 1,818,665 | 136.6M $ | as of Mar 31, 2026 |
| GOLDMAN SACHS GROUP INC | 1,699,847 | 127.6M $ | as of Mar 31, 2026 |
| AMERICAN CENTURY COMPANIES INC | 1,663,803 | 124.9M $ | as of Mar 31, 2026 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,583,266 | 118.9M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 1,575,023 | 118.3M $ | as of Mar 31, 2026 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,475,632 | 110.8M $ | as of Mar 31, 2026 |
| Pictet Asset Management Holding SA | 1,434,995 | 107.1M $ | as of Mar 31, 2026 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,404,033 | 105.4M $ | as of Mar 31, 2026 |
| Invesco Ltd. | 1,277,358 | 95.9M $ | as of Mar 31, 2026 |
| MILLENNIUM MANAGEMENT LLC | 1,051,506 | 79M $ | as of Mar 31, 2026 |
| MORGAN STANLEY | 1,026,509 | 77.1M $ | as of Mar 31, 2026 |