Funds holding Spyre Therapeutics Inc
227 funds declare a position · 41 ETFs and 186 other funds · 1.4B $· 33M SEK · US00773J2024
Other lines from the same issuer : Spyre Therapeutics, Inc. (US007CVR0207)
Each line carries its report date.
| Rank | Fund | Shares | Value | Weight | |
|---|---|---|---|---|---|
| 101 | iShares Russell 3000 ETF iShares Trust | 19,760 | 996.7K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 102 | Health Sciences Trust John Hancock Variable Insurance Trust | 19,484 | 982.8K $ | 0.43 % | as of Mar 31, 2026 · Original filing |
| 103 | Brighthouse/Wellington Large Cap Research Portfolio Brighthouse Funds Trust I | 19,129 | 964.9K $ | 0.04 % | as of Mar 31, 2026 · Original filing |
| 104 | ALGER HEALTH SCIENCES FUND ALGER FUNDS | 19,000 | 1.4M $ | 2.32 % | as of Apr 30, 2026 · Original filing |
| 105 | BIOTECHNOLOGY ULTRASECTOR PROFUND ProFunds | 18,961 | 1.4M $ | 0.77 % | as of Apr 30, 2026 · Original filing |
| 106 | Small-Cap Index Portfolio PACIFIC SELECT FUND | 17,971 | 906.5K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 107 | VANGUARD RUSSELL 2000 VALUE INDEX FUND VANGUARD SCOTTSDALE FUNDS | 17,163 | 738.2K $ | 0.07 % | as of Feb 28, 2026 · Original filing |
| 108 | MML Small Cap Growth Equity Fund MML SERIES INVESTMENT FUND | 16,059 | 810K $ | 0.61 % | as of Mar 31, 2026 · Original filing |
| 109 | U.S. Small Cap Equity Fund RUSSELL INVESTMENT CO | 15,757 | 1.2M $ | 0.12 % | as of Apr 30, 2026 · Original filing |
| 110 | Schwab Small-Cap Equity Fund SCHWAB CAPITAL TRUST | 15,681 | 1.2M $ | 0.16 % | as of Apr 30, 2026 · Original filing |
| 111 | Diversified Equity Master Portfolio Master Investment Portfolio | 14,530 | 732.9K $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 112 | BlackRock Advantage Small Cap Growth Fund BlackRock Funds | 14,235 | 718K $ | 0.11 % | as of Mar 31, 2026 · Original filing |
| 113 | EQ/T.Rowe Price Health Sciences Portfolio EQ Advisors Trust | 13,859 | 699K $ | 0.44 % | as of Mar 31, 2026 · Original filing |
| 114 | NVIT Small Cap Index Fund Nationwide Variable Insurance Trust | 13,678 | 689.9K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 115 | NYLIM VP Wellington Small Cap Portfolio NEW YORK LIFE INVESTMENTS VP FUNDS TRUST | 13,597 | 685.8K $ | 0.19 % | as of Mar 31, 2026 · Original filing |
| 116 | Small Cap Index Trust John Hancock Variable Insurance Trust | 12,492 | 630.1K $ | 0.11 % | as of Mar 31, 2026 · Original filing |
| 117 | T. Rowe Price Integrated U.S. Small-Mid Cap Core Equity Fund T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC. | 11,913 | 600.9K $ | 0.04 % | as of Mar 31, 2026 · Original filing |
| 118 | iShares Russell Small/Mid-Cap Index Fund BlackRock Funds | 11,707 | 871.6K $ | 0.07 % | as of Apr 30, 2026 · Original filing |
| 119 | iShares Morningstar Small-Cap Growth ETF iShares Trust | 11,637 | 866.4K $ | 0.09 % | as of Apr 30, 2026 · Original filing |
| 120 | SIIT EXTENDED MARKET INDEX FUND SEI INSTITUTIONAL INVESTMENTS TRUST | 11,300 | 486K $ | 0.04 % | as of Feb 28, 2026 · Original filing |
| 121 | BlackRock Advantage Small Cap Core Fund BlackRock Funds | 10,711 | 460.7K $ | 0.01 % | as of Feb 27, 2026 · Original filing |
| 122 | Fidelity Flex Small Cap Index Fund Fidelity Salem Street Trust | 10,286 | 765.8K $ | 0.19 % | as of Apr 30, 2026 · Original filing |
| 123 | T. Rowe Price Extended Equity Market Index Fund T. ROWE PRICE INDEX TRUST, INC. | 10,142 | 511.6K $ | 0.05 % | as of Mar 31, 2026 · Original filing |
| 124 | Bridge Builder Small/Mid Cap Value Fund Bridge Builder Trust | 10,106 | 509.7K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 125 | DWS Small Cap Index VIP DEUTSCHE DWS INVESTMENTS VIT FUNDS | 9,600 | 484.2K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 126 | Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF Goldman Sachs ETF Trust | 8,967 | 385.7K $ | 0.04 % | as of Feb 28, 2026 · Original filing |
| 127 | Blackstone Alternative Multi-Strategy Fund Blackstone Alternative Investment Funds | 8,850 | 446.4K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 128 | NYLI WMC Small Companies Fund NEW YORK LIFE INVESTMENTS FUNDS TRUST | 8,839 | 658.1K $ | 0.20 % | as of Apr 30, 2026 · Original filing |
| 129 | Bridge Builder Small/Mid Cap Growth Fund Bridge Builder Trust | 8,822 | 445K $ | 0.00 % | as of Mar 31, 2026 · Original filing |
| 130 | AST PGIM Aggressive Multi-Asset Portfolio Advanced Series Trust | 8,800 | 443.9K $ | 0.00 % | as of Mar 31, 2026 · Original filing |
| 131 | BlackRock Small Cap Index V.I. Fund BlackRock Variable Series Funds, Inc. | 8,489 | 428.2K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 132 | Multi-Manager U.S. Small Cap Equity Fund Goldman Sachs Trust II | 8,343 | 621.1K $ | 0.18 % | as of Apr 30, 2026 · Original filing |
| 133 | T. Rowe Price Small-Cap Index Fund T. ROWE PRICE INDEX TRUST, INC. | 8,289 | 418.1K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 134 | Virtus Biotech Clinical Trials Etf ETFis Series Trust I | 8,208 | 611.1K $ | 1.64 % | as of Apr 30, 2026 · Original filing |
| 135 | JPMorgan Small Cap Value Portfolio Brighthouse Funds Trust I | 8,156 | 411.4K $ | 0.13 % | as of Mar 31, 2026 · Original filing |
| 136 | SA Small Cap Index Portfolio SUNAMERICA SERIES TRUST | 8,016 | 596.8K $ | 0.17 % | as of Apr 30, 2026 · Original filing |
| 137 | Goldman Sachs Small Cap Equity Insights Fund Goldman Sachs Trust | 7,906 | 588.6K $ | 0.08 % | as of Apr 30, 2026 · Original filing |
| 138 | Carillon Chartwell Small Cap Fund Carillon Series Trust | 7,815 | 394.2K $ | 0.21 % | as of Mar 31, 2026 · Original filing |
| 139 | Victory Extended Market Index Fund Victory Portfolios III | 7,381 | 549.5K $ | 0.07 % | as of Apr 30, 2026 · Original filing |
| 140 | Voya RussellTM Small Cap Index Portfolio Voya VARIABLE PORTFOLIOS INC | 7,338 | 370.1K $ | 0.11 % | as of Mar 31, 2026 · Original filing |
| 141 | LVIP JPMorgan Small Cap Core Fund LINCOLN VARIABLE INSURANCE PRODUCTS TRUST | 7,274 | 366.9K $ | 0.18 % | as of Mar 31, 2026 · Original filing |
| 142 | AlphaCentric Life Sciences and Healthcare Fund MUTUAL FUND SERIES TRUST | 6,634 | 334.6K $ | 0.85 % | as of Mar 31, 2026 · Original filing |
| 143 | EQ/Morgan Stanley Small Cap Growth Portfolio EQ Advisors Trust | 6,210 | 313.2K $ | 0.08 % | as of Mar 31, 2026 · Original filing |
| 144 | Victory Pioneer Select Mid Cap Growth VCT Portfolio Victory Variable Insurance Funds II | 6,112 | 308.3K $ | 0.32 % | as of Mar 31, 2026 · Original filing |
| 145 | T. Rowe Price Total Equity Market Index Fund T. ROWE PRICE INDEX TRUST, INC. | 6,023 | 303.8K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 146 | Nationwide Small Cap Index Fund Nationwide Mutual Funds | 5,910 | 440K $ | 0.17 % | as of Apr 30, 2026 · Original filing |
| 147 | PROFUND VP BIOTECHNOLOGY ProFunds | 5,850 | 295.1K $ | 0.71 % | as of Mar 31, 2026 · Original filing |
| 148 | Brighthouse/Wellington Balanced Portfolio Brighthouse Funds Trust II | 5,669 | 285.9K $ | 0.03 % | as of Mar 31, 2026 · Original filing |
| 149 | VANGUARD RUSSELL 3000 INDEX FUND VANGUARD SCOTTSDALE FUNDS | 5,643 | 242.7K $ | 0.00 % | as of Feb 28, 2026 · Original filing |
| 150 | CVT Russell 2000 Small Cap Index Portfolio Calvert Variable Trust, Inc. | 5,593 | 282.1K $ | 0.11 % | as of Mar 31, 2026 · Original filing |
| 151 | First Trust Multi-Manager Small Cap Opportunities ETF First Trust Exchange-Traded Fund VIII | 5,493 | 236.3K $ | 0.52 % | as of Feb 28, 2026 · Original filing |
| 152 | Carillon Chartwell Small Cap Growth Fund Carillon Series Trust | 5,274 | 266K $ | 0.21 % | as of Mar 31, 2026 · Original filing |
| 153 | Venerable Small Cap Index Fund Venerable Variable Insurance Trust | 5,237 | 264.2K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 154 | iShares Morningstar Small-Cap Value ETF iShares Trust | 5,003 | 372.5K $ | 0.06 % | as of Apr 30, 2026 · Original filing |
| 155 | Invesco Russell 2000 Dynamic Multifactor ETF Invesco Exchange-Traded Self-Indexed Fund Trust | 4,922 | 211.7K $ | 0.08 % | as of Feb 28, 2026 · Original filing |
| 156 | Strategic Equity Allocation Trust John Hancock Variable Insurance Trust | 4,796 | 241.9K $ | 0.00 % | as of Mar 31, 2026 · Original filing |
| 157 | VY(R) JPMORGAN SMALL CAP CORE EQUITY PORTFOLIO Voya Investors Trust | 4,770 | 240.6K $ | 0.09 % | as of Mar 31, 2026 · Original filing |
| 158 | iShares Total U.S. Stock Market Index Fund BlackRock Funds | 4,592 | 341.9K $ | 0.01 % | as of Apr 30, 2026 · Original filing |
| 159 | VIP Extended Market Index Portfolio Variable Insurance Products Fund II | 4,582 | 231.1K $ | 0.05 % | as of Mar 31, 2026 · Original filing |
| 160 | Voya VACS Index Series SC Portfolio Voya VARIABLE PORTFOLIOS INC | 4,352 | 219.5K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 161 | Invesco Nasdaq Biotechnology ETF Invesco Exchange-Traded Fund Trust II | 4,352 | 187.2K $ | 0.25 % | as of Feb 28, 2026 · Original filing |
| 162 | ProShares Ultra Russell2000 ProShares Trust | 4,251 | 182.8K $ | 0.06 % | as of Feb 28, 2026 · Original filing |
| 163 | ProShares UltraPro Russell2000 ProShares Trust | 4,235 | 182.1K $ | 0.05 % | as of Feb 28, 2026 · Original filing |
| 164 | FlexShares Morningstar US Market Factor Tilt Index Fund FlexShares Trust | 4,004 | 298.1K $ | 0.01 % | as of Apr 30, 2026 · Original filing |
| 165 | ProShares Ultra Nasdaq Biotechnology ProShares Trust | 3,583 | 154.1K $ | 0.17 % | as of Feb 28, 2026 · Original filing |
| 166 | AVIP BlackRock Advantage Small Cap Growth Portfolio AuguStar Variable Insurance Products Fund Inc | 3,558 | 179.5K $ | 0.15 % | as of Mar 31, 2026 · Original filing |
| 167 | First Trust Nasdaq Pharmaceuticals ETF First Trust Exchange-Traded Fund VI | 3,533 | 178.2K $ | 0.61 % | as of Mar 31, 2026 · Original filing |
| 168 | PD Small-Cap Growth Index Portfolio PACIFIC SELECT FUND | 3,428 | 172.9K $ | 0.15 % | as of Mar 31, 2026 · Original filing |
| 169 | 1290 VT Small Cap Value Portfolio EQ Advisors Trust | 3,395 | 171.2K $ | 0.04 % | as of Mar 31, 2026 · Original filing |
| 170 | iShares MSCI World Small-Cap ETF iShares Trust | 3,375 | 145.2K $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 171 | Morgan Stanley Pathway Small-Mid Cap Equity ETF MORGAN STANLEY PATHWAY FUNDS | 3,017 | 129.8K $ | 0.02 % | as of Feb 28, 2026 · Original filing |
| 172 | ProShares Russell 2000 High Income ETF ProShares Trust | 2,987 | 128.5K $ | 0.08 % | as of Feb 28, 2026 · Original filing |
| 173 | Small Cap Core Fund Northern Funds | 2,928 | 147.7K $ | 0.04 % | as of Mar 31, 2026 · Original filing |
| 174 | iShares Morningstar Small-Cap ETF iShares Trust | 2,792 | 207.9K $ | 0.08 % | as of Apr 30, 2026 · Original filing |
| 175 | Goldman Sachs Variable Insurance Trust Small Cap Equity Insights Fund Goldman Sachs Variable Insurance Trust | 2,484 | 125.3K $ | 0.07 % | as of Mar 31, 2026 · Original filing |
| 176 | EQ/Franklin Small Cap Value Managed Volatility Portfolio EQ Advisors Trust | 2,193 | 110.6K $ | 0.05 % | as of Mar 31, 2026 · Original filing |
| 177 | PGIM Balanced Fund Prudential Investment Portfolios, Inc. | 2,100 | 105.9K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 178 | NVIT GS Small Cap Equity Insights Fund Nationwide Variable Insurance Trust | 2,056 | 103.7K $ | 0.05 % | as of Mar 31, 2026 · Original filing |
| 179 | PD Small-Cap Value Index Portfolio PACIFIC SELECT FUND | 1,927 | 97.2K $ | 0.08 % | as of Mar 31, 2026 · Original filing |
| 180 | Penn Series Small Cap Index Fund Penn Series Funds Inc | 1,900 | 95.8K $ | 0.12 % | as of Mar 31, 2026 · Original filing |
| 181 | Innovator U.S. Small Cap Managed Floor ETF Innovator ETFs Trust | 1,851 | 137.8K $ | 0.18 % | as of Apr 30, 2026 · Original filing |
| 182 | Allspring Disciplined Small Cap Fund ALLSPRING FUNDS TRUST | 1,709 | 86.2K $ | 0.06 % | as of Mar 31, 2026 · Original filing |
| 183 | Nationwide Fundamental All Cap Equity Portfolio Nationwide Mutual Funds | 1,656 | 123.3K $ | 0.01 % | as of Apr 30, 2026 · Original filing |
| 184 | State Street Total Return V.I.S. Fund STATE STREET VARIABLE INSURANCE SERIES FUNDS INC | 1,641 | 82.8K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 185 | SA Multi-Managed Small Cap Portfolio SEASONS SERIES TRUST | 1,634 | 82.4K $ | 0.06 % | as of Mar 31, 2026 · Original filing |
| 186 | VIP Total Market Index Portfolio Variable Insurance Products Fund II | 1,629 | 82.2K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 187 | Venerable US Small Cap Fund Venerable Variable Insurance Trust | 1,600 | 80.7K $ | 0.06 % | as of Mar 31, 2026 · Original filing |
| 188 | Eventide Small Cap ETF Strategy Shares | 1,513 | 112.6K $ | 0.44 % | as of Apr 30, 2026 · Original filing |
| 189 | JPMorgan Healthcare Leaders ETF J.P. Morgan Exchange-Traded Fund Trust | 1,327 | 98.8K $ | 0.89 % | as of Apr 30, 2026 · Original filing |
| 190 | Global Atlantic Wellington Research Managed Risk Portfolio Forethought Variable Insurance Trust | 1,309 | 66K $ | 0.03 % | as of Mar 31, 2026 · Original filing |
| 191 | Multimanager Aggressive Equity Portfolio EQ Advisors Trust | 1,300 | 65.6K $ | 0.00 % | as of Mar 31, 2026 · Original filing |
| 192 | Total Stock Market Index Trust John Hancock Variable Insurance Trust | 1,249 | 63K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 193 | SIMT Multi-Asset Inflation Managed Fund SEI INSTITUTIONAL MANAGED TRUST | 1,213 | 61.2K $ | 0.01 % | as of Mar 31, 2026 · Original filing |
| 194 | AQR Small Cap Momentum Style Fund AQR Funds | 1,207 | 60.9K $ | 0.04 % | as of Mar 31, 2026 · Original filing |
| 195 | Small-Cap Equity Portfolio PACIFIC SELECT FUND | 1,002 | 50.5K $ | 0.02 % | as of Mar 31, 2026 · Original filing |
| 196 | ULTRA SMALL CAP PROFUND ProFunds | 842 | 62.7K $ | 0.11 % | as of Apr 30, 2026 · Original filing |
| 197 | TIAA Separate Account VA-1 - Stock Index Account TIAA Separate Account VA-1 | 830 | 41.9K $ | 0.00 % | as of Mar 31, 2026 · Original filing |
| 198 | Fidelity Small Cap Stock K6 Fund Fidelity Concord Street Trust | 817 | 60.8K $ | 0.33 % | as of Apr 30, 2026 · Original filing |
| 199 | SmallCap Value Fund II Principal Funds, Inc | 798 | 59.4K $ | 0.00 % | as of Apr 30, 2026 · Original filing |
| 200 | Fidelity Flex Small Cap Focused Index Fund Fidelity Salem Street Trust | 549 | 40.9K $ | 0.26 % | as of Apr 30, 2026 · Original filing |
Institutional managers
189 managers declare this company to the SEC (Form 13F). These positions are not counted in the totals above: a manager and its own funds file separately.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 11,781,024 | 594.2M $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 5,521,221 | 278.5M $ | as of Mar 31, 2026 |
| RTW INVESTMENTS, LP | 4,171,996 | 210.4M $ | as of Mar 31, 2026 |
| Fairmount Funds Management LLC | 4,018,101 | 202.7M $ | as of Mar 31, 2026 |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 190.8M $ | as of Mar 31, 2026 |
| Venrock Adviser, LLC | 3,685,448 | 185.9M $ | as of Mar 31, 2026 |
| Driehaus Capital Management LLC | 2,790,785 | 140.8M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 2,607,031 | 131.5M $ | as of Mar 31, 2026 |
| Paradigm Biocapital Advisors LP | 1,957,266 | 98.7M $ | as of Mar 31, 2026 |
| Commodore Capital LP | 1,912,380 | 96.5M $ | as of Mar 31, 2026 |
| TCG Crossover Management, LLC | 1,900,582 | 95.9M $ | as of Mar 31, 2026 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 95.4M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | 92M $ | as of Mar 31, 2026 |
| Capital International Investors | 1,746,129 | 88.1M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 86.8M $ | as of Mar 31, 2026 |
| JANUS HENDERSON GROUP PLC | 1,656,164 | 83.6M $ | as of Mar 31, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | 81.8M $ | as of Mar 31, 2026 |
| Remedium Capital Partners, LLC | 1,456,231 | 73.5M $ | as of Mar 31, 2026 |
| Affinity Asset Advisors, LLC | 1,279,134 | 64.5M $ | as of Mar 31, 2026 |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 61.9M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 1,000,000 | 50.4M $ | as of Mar 31, 2026 |
| BRAIDWELL LP | 932,823 | 47.1M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 882,833 | 44.5M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 979,299 | 44.5M $ | as of Mar 31, 2026 |
| Caligan Partners LP | 878,127 | 44.3M $ | as of Mar 31, 2026 |